Alpha-lipoic acid (ALA) is a possible alternative remedy to treat the pain associated with diabetic polyneuropathy. Neuropathy, or nerve damage, is a common and potentially serious complication of diabetes. Nerve damage is permanent, and its symptoms can be difficult to alleviate. Polyneuropathy involves the peripheral nerves of the body. It’s the most common form of neuropathy in people who have diabetes, and it causes foot and leg pain.

Alpha-lipoic acid has gained a lot of attention in recent years. It’s an organic compound that acts as a powerful antioxidant in the body. Your body produces alpha-lipoic acid naturally, but it’s also found in a variety of foods and as a dietary supplement. Research suggests that it may play a role in weight loss, diabetes, and other health conditions. However, many people wonder whether it’s effective. This article reviews alpha-lipoic acid, its benefits, side effects, and recommended dosage.

Alpha-lipoic acid is an antioxidant. Although there is some evidence it may help treat conditions related to diabetes, confirming studies are needed. Alpha lipoic acid (ALA) is an endogenous cofactor found in cells that can also be obtained in the diet. It is sometimes referred to as a “universal antioxidant” because it is both water- and fat-soluble and can neutralize reactive oxygen species (26). It is marketed as a dietary supplement for this reason, and is also used as adjuvant therapy for neuropathy and to improve glycemic control. Preclinical studies show that ALA plays a crucial role in energy production, and exerts antioxidant and apoptotic effects.